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Pragmatic trials are trials designed to provide information for the real-world practice of clinical. They are often characterized as focusing on practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.
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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. However, too much heterogeneity can cause issues with the design of the trial.
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Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. Its software can be used on mobile devices and in multiple languages. It has earned itself the status of one of the top casino gaming platforms despite its relative infancy. The latest releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They also provide a useful method of determining the cause-effect relationship between the intervention and its effects. However, they shouldn't be used as a substitute for explanation studies.
The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study, including the recruitment, design, and delivery of the intervention and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to keep in mind, however, that the majority were conducted in primary-care settings.
