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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are typically focused on the practical aspects of study design, including the recruitment process and consent, adherence, and the use of routinely available equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for practical trials to be valid and also helps reduce bias in the results. Too much heterogeneity, however could cause issues with the trial design.
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The purpose of pragmatic trials is to replicate real-life scenarios and gain maximum validity externally. Usually, they are commissioned by policymakers and practitioners to guide their decisions. They are also a good way to identify the cause-effect relationship between an intervention and its results. They should, however, not, be used to replace the need for explanation studies.
The pragmatism idea is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, 프라그마틱 무료스핀 슬롯 사이트 - Https://Www.Bitsdujour.Com/Profiles/Uvbwp2, and pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, and monitoring.
There is an encouraging increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.
